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首页>>免疫学>>一抗>>Rabbit anti-E2F3 Polyclonal antibody
Rabbit anti-E2F3 Polyclonal antibody
  • 产品货号:
    BN40667R
  • 中文名称:
    Rabbit anti-E2F3 Polyclonal antibody
  • 品牌:
    Biorigin
  • 货号

    产品规格

    售价

    备注

  • BN40667R-100ul

    100ul

    ¥2120.00

    交叉反应(总):Human,Mouse,Rat,Dog,Horse,Rabbit,;推荐应用:IHC-P,

  • BN40667R-200ul

    200ul

    ¥3140.00

    交叉反应(总):Human,Mouse,Rat,Dog,Horse,Rabbit,;推荐应用:IHC-P,

产品描述

英文名称E2F3
中文名称转录因子E2F-3抗体
别    名DKFZp686C18211; E2F 3; E2F transcription factor 3; KIAA0075; MGC104598; Transcription factor E2F 3; E2F3_HUMAN; Transcription factor E2F3; E2F-3.  
研究领域免疫学  染色质和核信号  转录调节因子  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Dog, Horse, Rabbit, )
产品应用IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量49kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human E2F3:91-190/465 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. [provided by RefSeq].

Function:
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner.

Subunit:
Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with TFDP1/Dp-1 to E2F sites. Interacts with retinoblastoma protein RB1 and related proteins (such as RBL1) that inhibit the E2F transactivation domain. Binds EAPP.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the E2F/DP family.

SWISS:
O00716

Gene ID:
1871

Database links:
Entrez Gene: 1871 Human

GenBank: AAH16847 Human

Omim: 600427 Human

SwissProt: O00716 Human

Unigene: 269408 Human

Unigene: 703174 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

转录调节因子(Transcriptin Regulators) E2F3转录因子具有调控细胞增殖、分化和凋亡相关基因转录的重要作用.


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